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Science & Humans
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Written by
Science & Humans
Medically approved by
Maria Jacob
Last updated
9/14/2024 5:30:00 AM
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Contrave is an effective weight-loss medication, and as with any drug, it may cause side effects, especially in the first few weeks. Most common side effects are mild and temporary and can be managed with ease by maintaining a balanced diet or taking OTC medicines. Serious and rare side effects of Contrave require immediate medical attention. Understanding the side effects and how to manage them successfully increases the safety and effectiveness of the treatment.
Obesity is a problem worldwide, and many medications have been produced in order to help people manage their weight. Each individual has unique problems, lifestyle, and medical history. A medicine that works for one may not work for the other. Amongst these medications, Contrave has seen quite a rise.
Contrave is approved by the Food and Drug Administration as a weight loss drug. It is a combination medication that has two active components, naltrexone and bupropion. While separately these two are prescribed to treat opioid dependency and depression respectively, together in Contrave they work wonders to reduce appetite. It is given to people who are overweight, obese, or who have weight-related ailments.
Both the components work hand-in-hand to produce the desired results. Bupropion ensures an increase of POMC cells that secrete a hormone called alpha-MSH which activates receptors responsible for food intake. It leads to energy expenditure, reduced appetite and cravings, and an enhanced mood.
Naltrexone by itself is supposed to be an opioid antagonist and fulfills this role by blocking an opioid receptor responsible for reducing the functionality of POMC cells, indirectly ensuring an increase of POMC cells. Together they put in motion a process that leads to weight loss by reducing hunger and cravings.
Contrave has a list of side effects, most of them common and mild. They are often temporary and heal with time. Most of these can be classified under gastrointestinal, neurological, and cardiovascular side effects for easier understanding.
Contrave’s side effects can sometimes be serious and demand immediate consultation with a medical professional. These are rare, but once you notice their symptoms, it is advised that you don’t delay visiting your doctor. These include seizures, risk of suicidal thoughts/behaviors, liver problems, and severe allergic reactions.
Seizures can be dangerous on their own. It is one of the reasons you should disclose your medical history transparently to your healthcare provider. If you have ever had seizures before, Contrave increases the risk of having them again.
Talk to your doctor immediately if you experience a seizure. Your doctor may try a different weight-loss method for you.
Each individual reacts uniquely to various drugs. Having the option of switching between medications makes it easier in case you see signs of an allergic reaction towards one of them. An allergic reaction by Contrave can have signs like skin rashes, skin flushes, itchiness, swelling (of skin under your eyes or of mouth/tongue), and difficulty in breathing.
Immediately visit your doctor if you observe any of these signs. They may give you a medicine to relieve your symptoms or a cream to deal with the rashes. If they still do not subside, the doctor may switch your weight-loss drug.
The list of Contrave’s side effects includes liver damage or hepatitis (inflammation of the liver). Symptoms include dark urine, signs of jaundice (yellowing of the skin/eyes), abdominal pain, or fatigue.
The liver is one of the organs responsible for flushing the drug out of the body, so if it is damaged, the drug can build up in your system. This could increase other side effects of Contrave. Make sure you keep a lookout for any signs of liver or kidney ailments. If you do observe any, consult your doctor for further steps.
Do side effects of Contrave go away? Most often the common side effects of Contrave do subside over time. They are usually manageable. If you face any symptom that remains for a long duration and causes you discomfort or pain, or is one of the severe side effects of Contrave, notify your healthcare professional immediately. There are safety precautions that you should take note of to make an informed decision.
Before taking any supplements or medications you aren’t sure of, take the advice of your doctor.
If you observe any symptom, take appropriate action towards it. Ignoring it may worsen your side effects or cause other severe ailments. If you notice any severe symptom of a side effect, consulting a healthcare provider will lead to them reconsidering the treatment plan. They may advice precautions, alter dosage, or change medications.
Staying sufficiently hydrated can mild down many of Contrave’s side effects. When your body lacks the necessary water content, it can get dehydrated. That can cause dizziness, fatigue, headaches, etc. To avoid such side effects, make sure you eat fresh fruits that are water-based like watermelons and drink plenty of water.
Exercise helps build tolerance and allows flexibility. Side effects of Contrave such as dizziness, headaches, and the risk of cardiovascular issues are less likely to cause trouble if you exercise regularly.
Additionally, having quality sleep is important for your mind and body. Sleeping for 7-9 hours is necessary for every adult, especially when you are at risk for insomnia. Maintain a proper sleep schedule and try your best to adhere to it. Some things that may help you sleep better are soothing music, warm showers, and avoiding screen time before bed.
To track your progress, dosage, and side effects, have regular check-ups with your healthcare provider. That will allow them to adjust your dosage if required before your symptoms take a turn for the worse.
Contrave’s reviews are generally positive. It is rated 6.6 out of 10 on some sources and 3.5 out of 5 on others. People who have taken Contrave for 6 months or longer gave their thumbs up for Contrave. They noted their cravings went down, consumption of sugary drinks went down, and alcohol consumption stopped with ease.
The first few weeks on Contrave brought people some common side effects like constipation, headaches, and disturbed sleep. Vomiting and a dry mouth are a few rarer side effects noted by them.
Positive feedback included how people learned to listen to their bodies and eat what their bodies actually needed. They also emphasize that Contrave is not a “magic pill” and must be paired with a good diet.
Canada observes similar reviews on Contrave. People on different treatment plans that did not work for them were delighted to find Contrave in the market. Some of them noted an absence of food cravings which lead to an improved quality of life. When few of them did face side effects, they also noted how the side effects subsided with time. Amongst the people of Canada, only one noted experience of nausea, flashes, and unbearable ear ringing that was severe even after discontinuation of the drug.
People on Contrave had fewer complaints of pancreatitis compared to semaglutide drugs according to some studies. Contrave is available all over Canada, though some provinces may or may not have government-funded drug plans for Contrave.
Contrave is quite effective as a weight-loss drug. It is taken as a tablet(s) and shows its impact in 4 weeks! During this time and post this, there are certain side effects that people may face. Most common side effects are mild and temporary and can be managed with over-the-counter medicines. Serious side effects, though they are rare, can be a cause of alarm. Seek immediate medical help if you notice any signs of a serious side effect or persistent signs of a common side effect.
To ensure minimum side effects, take care in choosing your healthcare provider. Talk to them in detail about your lifestyle, medical history, and your journey with Contrave. Keep them in the loop by visiting them periodically so that they can alter your dosage accordingly.
Monitor your heart rate and blood pressure consistently to avoid any cardiovascular ailment, and proactively manage your side effects without ignoring them for maximum effectiveness of the treatment. Try your best to stay committed to your balanced diet and exercise regime. Drink plenty of water and sleep on time to grow into a healthier body.
The most commonly reported side effects of Contrave noticed in the first week or two are nausea, vomiting, headache, dizziness, and insomnia. Reports of seizures or heart issues are rare. To ensure adequate management or avoidance of these side effects, discuss your dosage with your healthcare provider. Ensure you start at the lowest dose and gradually increase.
Most side effects are temporary and subside once the body gets used to the medication. If they don’t, visit your doctor for management strategies that suit you the best.
Contrave causes a list of gastrointestinal side effects, including gas and bloating. To manage them you can make dietary adjustments and drink more water. Before taking any medication, ensure that it does not interact with Contrave.
Some people noticed a difference in their weight within the first 4 weeks of taking Contrave. Take note, weight-loss by Contrave is a long journey, and you may see the desired results only after months of taking Contrave, exercising, and maintaining a balanced diet. How quickly Contrave starts working depends on individual metabolism, lifestyle changes, dosage, and overall health.
Discuss your medical history with your healthcare provider before you commit to Contrave. It is advised that if you experience seizures, hypertension, or depression, you may reconsider your treatment plan. Your medical conditions also decide your dosage and if you should go for alternative treatments, so make sure you let your doctor know everything.
Most people note a substantial weight loss and improved overall well-being. Some report gastrointestinal discomfort/pain or mood fluctuations. Regular check-ups help monitor signs of such side effects and manage any long-term effects.
Drug-to-drug interactions of Contrave can be an issue. Before taking any medication or supplement, consult your healthcare provider. Some medicines like blood pressure medications, antidepressants, or opioids may interfere with the effectiveness of the medication. If you are on any such medication, keep your body in check. If you notice any sign of a side effect, your doctor may adjust the dosage to suit you better.
Skip the missed dose and take your next dose of Contrave as per schedule. Do not take two doses at once. Try to avoid missing a dose, and if you miss more than once, consult your healthcare provider. Set reminders which can help you adhere to the dosing schedule.
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